Biology 350 Exam 20 questions 5 points each Spring 2018 1 In order for most canc
ID: 214244 • Letter: B
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Biology 350 Exam 20 questions 5 points each Spring 2018 1 In order for most cancers to develop, there must be an increase in genomic instability. A. True B. False 2. Cancer is the result of cumulated mutations within a singlecl umancan rutagens that demage DNA Consistent with this observation, most agents that A. True B. False 3. There are essentially two distinct 'Restriction points' (R1 and R2) depending on where you start the cell cycle. 4. FLIP blocks the death by design pathway by interiering with the death domain (DD) on the death receplor (CO96, 5. The Ink4 locus expresses two genes-Ink4 and Arf- that prevent Rb hypophosphorylation and destabilize p53 A. True B. False A. True B False respectfully A. True B. False 6. Cancer is thought to arise from adult stem ceils because of their limited potency to differentiae. A. True B. False 7. Loss of mitochondrial function during apoptosis is caused by cytochrome c release from the mitochondria, which disrupts the flow of electrons to oxygen in the electron transport chain. A. True B. False 8. Caffeine is a suppressor of the B-adrenergic response virtue of suppressing a phosphodiesterase that convets CAMP AMP A. True B. False 9Oncogenic Ras proteins have mutations that have increased kor that resuls in acceierated tydroljysis of GTP A. True B. False 10. Inhibition of protein synthesis in cancer cells leads to apoptotic cell death in response to serum depnivation) A. True B. FaiseExplanation / Answer
1. TRUE
Genomic instability is a characteristic feature of most of the cancers.
2. TRUE
Mutations must occur in a progenitor cell or in a differentiated cell so that it can produce a large number of progeny cells. The mutations must be transmitted from one cell to the other. hence, they must be in the genome.
3. FALSE
Restriction point = Cell cycle checkpoint. There are three major cell cycle checkpoints.
4. TRUE
FLICE-like inhibitory protein (FLIP) blocks FADD-mediated cell death by interfering with the activation of caspase-8.
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