BICD100 NAME Section # rd. Turin in your answers with your in-lecture final exam
ID: 214179 • Letter: B
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BICD100 NAME Section # rd. Turin in your answers with your in-lecture final exam on Friday, March 23 1.You study two rat strains, "Rose" and "Basil: both strains show high incidence of aborted fetuses if crossed with normal rats. "Rose" was exposed to X-irradiation while she was an embryo; "Basil" was treated with the reagent found in herbicide formula during embryogenesis. Below is the data you collected on the aborted fetuses Mother Rose Basil Sex of aborted fetuses Female Female and male Karyotype of aborted fetuses No Barr bodies All X chromosomes form Barr bodies Note: Below questions are not about what defect the X-ray/mutagen treatment has caused; the questions are about what makes the offspring die or not die Explain why A) All of Rose's daughters die B) All of Rose's sons survive C) All of Basil's offspring die 2.The first human oncovirus was discovered in 1964. Today, a "tumor virus" or "cancer virus" is any virus with a DNA or RNA genome that can cause cancer. Hence, they are classified as either "DNA oncovirus" or "RNA oncovirus". Research them, then choose one. Using no more than two paragraphs (1/2 page max, single-spaced), briefly explain the basic mechanisms of action by which the virus you chose causes cancer (you may refer to lecture slides at the end of L15, but make sure that your search goes beyond that). Cite your source of information at the end of your answer.Explanation / Answer
2. Human papillomavirus : HPV are highly infectious which causes anus, vulva and many such cancers, as those are caused by sexual transmission. HPV causes cancer by invading into the epithelium region, since the entire life cycle of HPV takes place only in epithelium region. HPV accelerates infection by suppres the immune system locally but it never causes cell death, inflammation or viraemia. In the cervical epithelium, the persistance of infection and cofactors leads to cancer. HPV encodes seven early proteins and two late proteins, which performs several viral infections including, viral DNA replication, gene expression regulation, particle assembly and release and membrane signaling. Early proteins E1 and E2 replication causes genomic stress which resulted in normal DNA breakage. The broken DNA contains one flanking region and intact HPV genome and that can be ligated to form viral-human hybrid episome.
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