8. Malonate is a competitive inhibitor of succinate dehydrogenase. If malonate i

Question

8. Malonate is a competitive inhibitor of succinate dehydrogenase. If malonate is added to a mitochondrial preparation that is oxidizing pyruvate as a substrate, which of the following compounds would you expect to decrease in concentration? A) Citrate B) Fumarate C) Isocitrate D) Pyruvate E) Succinate 9. The reaction of the citric acid cycle that produces an ATP equivalent (in the form of GTP) by substrate level phosphorylation is the conversion of: A) citrate to isocitrate. B) fumarate to malate C) malate to oxaloacetate D) succinate to fumarate E) succinyl-CoA to succinate 10. If the 16-carbon saturated fatty acid palmitate is oxidized completely to carbon dioxide and water (via the p-oxidation pathway and the citric acid cycle), and all of the energy-conserving products are used to drive ATP synthesis in the mitochondrion, the net yield of ATP per molecule of palmitate is B) 10 C) 25 D) 108 E) 1,000 11. Which of the following statements apply (applies) to the ß oxidation of fatty acids? 1. The process takes place in the cytosol of mammalian cells. 2. Carbon atoms are removed from the acyl chain one at a time 3. Before oxidation, fatty acids must be converted to their CoA derivatives 4. NADP is the electron acceptor 5. The products of ß oxidation can directly enter the citric acid cycle for further oxidation A) B) C) D) E) 1 and 3 only 1,2, and 3 1,2, and 5 3 and 5 only 4 only 12. If a person's urine contains unusually high concentrations of urea, which one of the following diets has he or she probably been eating recently? A) High carbohydrate, very low protein B) Very high carbohydrate, no protein, no fat C) Very high fat, high carbohydrate, no protein D) Very high fat, very low protein E) Very low carbohydrate, very high protein 13. Fill in the blanks (21 points) (a) In glycolysis, glucose is converted to 2__with a net yield of_ATP, and 2 (b) The major production of ATP during aerobic metabolism occurs when electrons from and are ultimately transferred to

Explanation / Answer

8. Option E is correct.
The reaction catalyzed by succinate dehydrogenase is,
Succinate + FAD+ ---------> Fumarate + FADH2
So, if the enzyme is inhibited, it's substrate i.e. succinate is accumulated.

9. Option E is correct.
Succinyl CoA + GDP + Pi -------> Succinate + GTP + CoA

10. Option D is correct.
Palmitate oxidation:
9 Acetyl CoA, 9 FADH and 9 NADH = 108 ATP

11. Option D is correct.
Fatty acids must be converted to CoA derivatives before their oxidation.
Fatty acid oxidation produces Acetyl CoA which can directly enter TCA cycle.

Related Questions

Navigate

• Browse (All)
• Browse 8
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.