1) In a given organism, exposure to a hormonal signal (e.g. epinephrine) trigger
ID: 213956 • Letter: 1
Question
1) In a given organism, exposure to a hormonal signal (e.g. epinephrine) triggers different responses in different tissues, and some tissues show no response at all. Which of the following is NOT a possible explanation for this phenomenon (except in rare exceptions)?
Activation of the same effector protein in different cells might cause different responses depending on what other proteins are expressed in the cells.
2) Which of the following is NOT associated with canonical G-protein coupled receptor (GPCR) signaling?
The receptor becomes phosphorylated and gets inactivated through binding with an inhibitory protein.
3) Which of the following statements about G-protein-coupled receptors (GPCRs) is FALSE?
Different GPCRs can be found in the plasma membrane, the cytosol or in the nucleus depending on the solubility and size of their ligands.
4) Which of the following statements about Ras signaling is TRUE?
Ras is activated by adenylyl cyclase and Ca2+.
5) Which of the following statements about Notch signaling is FALSE?
Notch signaling is important in the differentiation of nerve cells during development.
6) Which of the following statements about crosstalk is correct?
A) Different cell types might express different (or no) receptors for the hormone.Explanation / Answer
Q.1ans:- D Different cell types might contain different genes that control different responses. Rest of the option are possibilities for different responses from the cells. But Even if cells are of different types they all contain same genes in organism's body. Their expression is different and hence response is different.
Q.2 Ans:- Ras monomeric GTPase gets activated..During GPCR signalling Ras GTPase do not get activated. Because Ras-GTP bound is its active form.
Q.3 Ans:- Different GPCRs can be found in the plasma membrane, the cytosol or in the nucleus depending on the solubility and size of their ligands. This is not true regarding GPCR.
Because these cell surface recepetors than spans the plasma membrane 7 times. They are not present in nuclues. cytosol only contain cytosolic domain of GPCR associated with extracellular domain of GPCR.
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