1. (10 pts.) The recommended daily allowance for the vitamin Niacin is 15 mg/day

Question

1. (10 pts.) The recommended daily allowance for the vitamin Niacin is 15 mg/day. How would glycolysis be affected by Niacin deficiency? 2. (10 pts.) You recall that BPG, or 2,3-bisphosphoglycerate, binds to hemoglobin and lowers the affinity of hemoglobin for oxygen. BPG is formed from 1,3- bisphosphoglycerate in a detour from the glycolytic pathway. The level of glycolytic intermediates affects the oxygen affinity of hemoglobin through the mediation of BPG With this information, which of the following scenarios is likely to be observed in a man who suffers from a pyruvate kinase deficiency of the red blood cells? A. His hemoglobin has an abnormally high affinity for oxygen. B. His red blood cells contain abnormally low levels of 2,3-bisphosphoglycerate. C. His hemoglobin has an abnormally low affinity for oxygen. D. He exhibits high concenetrations of lactate in the blood. E. His red blood cells contain high levels of ATP

Explanation / Answer

1. Glycolysis would be impaired by niacin deficiency because the conversion of glyceraldehyde 3 phosphate to 1,3 bisphosphoglycerate would be affected. Therefore glycolysis would takes place less effectively.

2. A. His hameoglobin has an abnormally high affinity for oxygen

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