Each dropdown box (blank) has the following options: 1) Activates liver phosphor

Question

Each dropdown box (blank) has the following options:

1) Activates liver phosphorylase A

2) Activates liver phosphorylase B

3) Inhibits liver phosphorylase A

4) Inhibits liver phosphorylase B

5) Activates muscle phosphorylase A

6) Activates muscle phosphorylase B

7) Inhibits muscle phosphorylase A

8) Inhibits muscle phosphorylase  B

The muscle and liver forms of glycogen synthase respond to different allosteric effectors consistent with the energy status of a given tissue. Select the correct type of regulation with the correct isozyme AMP ATP Glucose Glucose 6-phosphate

Explanation / Answer

Liver glycogen helps to maintain blood glucose levels whereas muscle glycogen helps for muscle contraction. Liver is responsive to glucose but unresponsive to AMP.

In muscle cell, high AMP acts as second messenger and it activates phosphorylase A (active form) during excercise where energy required is high. But in resting muscle cell, phosphorylase B predominates (inactive form).

AMP : Activates muscle phosphorylase A and Inhibits muscle phosphorylase  B

ATP : Inhibits muscle phosphorylase A and Activates muscle phosphorylase B

ATP : Inhibits liver phosphorylase A and Activates liver phosphorylase B

Glucose - 6 - phosphate : Inhibits muscle phosphorylase A and Activates muscle phosphorylase B.

Glucose - 6 - phosphate : Inhibits liver phosphorylase A and Activates liver phosphorylase B.

Glucose : Inhibits liver phosphorylase A and Activates liver phosphorylase B. When blood glucose levels are high, it initiates glycogen synthesis.

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