Exercise for a search: What is 2013 NK13 ? Please choose the correct answer a) A

Question

Exercise for a search: What is 2013 NK13 ? Please choose the correct answer a) A new siRNA producing promising results in cancer therapy b) A newly discovered prion c) NK13 protein with the 2015 aa isoform d) Something that definitely exists in nature, but not a biomolecule e) a project of a water consuming car that does not need gasoline f) None of the above.

Having realized what “2015 NK13” means, please list its 5 most important properties catalogued by the huge government organization very interested in 2015 NK13 and its numerous cousins. Use correct scientific terminology used by that governmental and give the full name of the program.

Explanation / Answer

Option C.

NK13 is a protein. Serpinb6b is the name of the gene.

NK13 has serine-type endopeptidase inhibitor activity.

Endopeptidase/Serine protease is an enzyme which cleaves the peptide bonds in a polypeptide. It has serine residue in its active site.

Protease can be classified into two types based on its activity. One which cleave the non-terminal bond are termed as endopeptidase. whereas one which cleave the terminal bond are termed as exopeptidase.

NK13 being an inhibitor of serine protease has wide range of application in drug/parmaceutical industry.

Some of the endopeptidase inhibitors drug comes under the following categories,

Trypsin inhibitor - Leupeptin drug (Naturally occuring) which inhibits cysteine, serine and threonine peptidases.

Neprilysin (membrane metallo-endopeptidase/ neutral endopeptidase) inhibitor - Racecadotril an an antidiarrheal drug.

Renin (Hormones secreted from juxtaglomerular kidney cells) inhibitors - Aliskiren drug is used for patients with hypretension.

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