you are studying eukaryotic transcription using yeast as a model organism. What

Question

you are studying eukaryotic transcription using yeast as a model organism. What effect would you expect this mutation to have ? Periodic Table il Calculator on 10 of 12 Sapling Learning this question has been customied by Amy Hulme at Missouri State University eukaryotic transcription using yeast as a model organism. One strain of yeast has You are s mutations that disrupt HDAC activity. What effect would you expect this mutation to have O no change in transcription O overall decrease in transcription O overall increase in transcription search F3 F4

Explanation / Answer

Ans. The mutation in the yeast that disrupt the HDAC activity, there will be no change in the transcription.

Because studies have shown that these mutants are defective for the transcription repression (no transcription).

Yeast contains a protein complex Rpd3 histone deacetylase and Sin3 corepressor. This Sin3-Rpd3 complex if added to the added to the promoter region causes reduced or no transcription of the target genes. For such regression, histone deacetylase activity (HDAC) of Rpd3 is quite important. But this mutation is usually defective in the yeast and it does not have any effect on the transcription.

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