crossover products that are true recombinants can form after the resolution of H
ID: 212966 • Letter: C
Question
crossover products that are true recombinants can form after the resolution of Holliday junction during homologous recombination between two nearly identical parental duplexes. Which of the following answers best describes the characteristics of these recombination products?
a) each product contains heteroduplex DNA in the region of recombination, while the genes in the flanking regions are exchanged
b) each product contains heteroduplex DNA in the region of recombination, while the genes in the flanking regions become exchanged
c) each product contains heteroduplex DNA in the region of recombination, while the genes in the flanking regions do not become exchanged
d) One product contains heteroduplex DNA in the region of recombination, while the other contains homoduplex DNA in this same region. the genes in the flanking regions of bother products become exchanged
e) none of the above.
Explanation / Answer
The answer will be option a or b (as both options are identical, i.e., they are same).
In Holliday model of recombination, each invading parental strand is joins to the broken end of the other parental DNA molecule, thus creating a Holliday junction & begins to displace the original complementary strand ("Branch migration'). Thus the two nucleotide strands exchange positions & creating two heteroduplex DNA. Then rotation & cleavage in the vertical plane & successively rejoining of cleaved nucleotide produce two cross-over recombinants whose flanking regions are exchanged.
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