DISCUSSION 1. Discuss the importance of actin filaments and 4. What are the targ
ID: 212433 • Letter: D
Question
DISCUSSION 1. Discuss the importance of actin filaments and 4. What are the targets of phalloidin and taxol? What tors in the movement of cilia and fla- are their possible effects on cell motility? gella, and amoeboid movement. 5. Taxol slows tumor growth by stabilizing the 2. Discuss the importance of microtubules and kine microtubules of the mitotic spindle and prevent- ing mitosis. Using what you know about the role of the tubulin cytoskeleton, discuss the possible side effects of this treatment in a single cell and sin/dynein motors in the movement of cilia and flagella, and amoeboid movement 3. What are the targets of AMP-PNP, BDM, and within a patient. Orthovanadate? What are their possible effects on cell motility?Explanation / Answer
1. All these movements result from an interaction between the actin fillament and myosin motor that generate the movement relative to one another.The molecular basis for this interaction is the binding of myosin and actin to allow them to function as a motor fillament that drives the sliding.
2. Stable microtubules are found in cilia and flagella.This movement is caused by the motor protein dyenin,which uses the energy of ATP hydrolysis to move along the microtubules,in a manner resembling the movement of myosin along actin fillaments.
3. The target of AMP-PNP is kinesin-microtubule complex and target of BDM is myosin and target of orthovanadate is microtubules.
Orthovanadate effects the cell motility by assembling and disassembling microtubules.
BDM inhibits myosin and influence intracellular concentration of calcium thus it effects on cell motility.
AMP-PNP is ATP analog and stabilizes a kinesin-microtubule complex thus it inhibits the movement of cell.
4. Phalloidin targets actin cytoskeleton and it affects on cell motility by inhibiting cell movement like locomotion and cytokinesis.
Taxol targets microtubules and it affects on cell motility by losing of microtubules.
5. Tubulin cytoskeleton polymerises into microtubules.The side effect will be slow growth of normal tissues even in a single cell within a patient
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