Multiple Choice (Answer all multiple choice 50 pts) 1. What is the source of the

Question

Multiple Choice (Answer all multiple choice 50 pts) 1. What is the source of the quanta that make up the EPP? a. Pulses of current that flow through the electrical synapse b. Fusion of individual synaptic vesicles with the plasma membrane c. Individual action potentials d. Current through a single ion channel 2. The catalytic domain of a protein kinase a. transfers a carboxyl group to the relevant amino acid of the target protein. b. transfers a phosphate group to the relevant amino acid of the target protein. c. transfers ATP to the relevant amino acid of the target protein. d. binds to IP3 3. How would application of an intracellular Ca2 chelator affect the function of a synapse? a. It would decrease the magnitude of postsynaptic potential. b. It would eliminate the postsynaptic potential but have no effect on presynaptic potential. c. It would eliminate the postsynaptic potential and Ca2+-dependent vesicle fusion. ffect on the postsynaptic potential. 4 Most enzyme-linked receptors affect the function of the target cell by

Explanation / Answer

1.
Ans: B
neurotransmitter-filled vesicles are the quanta that will be released into the synapse. Quantal vesicles release their contents into the synapse by binding to the presynaptic membrane and combining their phospholipid bilayers.
2.
Ans: B
A protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation). Phosphorylation usually results in a functional change of the target protein (substrate) by changing enzyme activity, cellular location, or association with other proteins.
3.
Ans: C
When an action potential invades a presynaptic terminal, Ca2+ inflow through voltage-gated Ca2+ channels leads to a rise in intracellular Ca2+concentration. Next, Ca2+ binds to a presynaptic Ca2+ sensor, which subsequently triggers exocytosis of neurotransmitter-containing synaptic vesicles. Finally, the released transmitter diffuses across the synaptic cleft and binds to postsynaptic receptors. Thus, a voltage change in the presynaptic neuron (the action potential) is converted into two chemical signals (Ca2+ and transmitter) and then converted into an electrical response in the postsynaptic cell.

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