2. Consider a liver cell carrying out the oxidation glucose under aerobic condit

Question

2. Consider a liver cell carrying out the oxidation glucose under aerobic conditions. Suppose that we added a potent and specific inhibitor of mitochondrial ATP synthase. Tell whether each of the following statements about the effect of this inhibitor is true or false; if false explain why. ATP production in the cell will drop to zero. The rate of glucose consumption by this cell will decrease sharply. The rate of oxygen consumption will increase The citric acid cycle will speed up to compensate a. b. c. d.

Explanation / Answer

a False. the ATP synthesis will discontinue in mitochondria, but in order to remunerate cells will accelerate the generation of ATP by glycolysis, which will prevent ATP levels from dropping to zero.

b False. The acceleration of glycolysis ctually increases the speed of glucose consumption.

c False. as the electron transfer through the respiratory chain is tightly linked to ATP synthesis, blocking ATP synthase will block the electron flow and oxygen consumption.

d True. the rate of glucose consumption increases which in turn will produce more pyruvate leading to speeding up of Krebbs or citric cycle and ATP inhibits citric acid cycle as well.

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