NOTE: Individuals whose phenotype or genotype cannot be determined a unless othe

Question

NOTE: Individuals whose phenotype or genotype cannot be determined a unless otherwise indicated. re assumed to be homozygous normal, 1. Consider the following pedigree, 1a What is the most likely mode of inheritance for the trait? 12 pts] 1b. What key feature(s) of the pedigree were important in determining the answer to part 1a? [4 pts 1c. Assign an appropriate allele pair for the gene responsible for the trait and assign possible genotypes to the al individuals in the pedigree. [5 pts, 0.5 pts each] 1-1 1-2,- II-1 11-21-3_I-4 Ill-1--III-2-_ [11-3111-4- 1d. If individual Il-6 marries a male lacking the trait, what is the chance that their first son will ha 4 pts)

Explanation / Answer

Answer:

a. X-linked dominant

b. All daughters of an affected male are affected, therefore it is likely to be X-linked.

Can’t be X-linked recessive as individuals I-1 (XrXr) and I-2 (XRY) couldn’t produce an affected daughter (II-1) who   would have to have the genotype XrXr.

c. XT = affected allele and Xt = normal allele.

    I-1 = XTXt          I-2 = XtY

    II-1 = XTXt         II-2 = XtXt             II-3 = XtY               II-4 = XTY

    III-1 = XTXt           III-2 = XtY             III-3 = XtY             III-4 = XTXt           III-5 = XTXt           III-6 = XTXt

d. XTXt x XtY

F1: XTXt, XTY, XtXt, XtY

50% chance

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