14. The following diagram represents a substrate that is bound to the active sit

Question

14. The following diagram represents a substrate that is bound to the active site of an (blue ribbon represents the enzyme backbone and the R groups of 3 amino acids are drawn inside the pocket). Each circled interaction is important for the binding of the substrate to the enzyme. LOOK CLOSELY AT THE FIGURE BEFORE ANSWERING! In the table below, state the type of bond/interaction that can occur between the R groups of amino acids X, Y and Z enzyme at the active site of the enzyme and the substrate in gray circles. Complete table on answer sheet (1 pt ea) Amino Hydrogen bond, lonic bond, substrate Acid hydrophobic interaction H3C Esterase active site Extra credit: Which of the amino acids (X, Y or Z) is closest to the N terminus of the primary sequence of the enzyme? Put on answer sheet (1 pt)

Explanation / Answer

X - Hydrogen Bond ( Due to the presence of a hydrogen on a highly EN atom and Oxygen)

Y - Hydrophobic Interaction (between the methyl and H)

Z - Hydrophobic Interaction ( Due to the presence of two methyls), repulsion betwen the methyl groups

X will be closest to the N terminus of the primary sequence of the enzyme as it is the strongest force among all the above mentioned one's and it is attractive in nature.

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