Scientists have observed temporary suppression of B cell development in bone mar

Question

Scientists have observed temporary suppression of B cell development in bone marrow during infection with a number of viruses, including hepatitis A, B, and C, influenza, and parvovirus B19.

Given what you know about B cell development, provide 2 hypotheses to explain this phenomenon, one focusing on why the host might choose suppress B cell development, and the other focusing on why the virus might do this.

Also, hypothesize why this sort of development suppression is seen with viral infections, but not with bacterial infections, even very severe bacterial blood infections.

Explanation / Answer

B Cells has key role for both innate and adaptive immunity by producing antibodies ( specialist for adaptive rensponses). Studies shows that up-regulation of PTEN (Phosphatase & tensin homolog) responsible for defects in B lymphocytes & antibodies responses. Viral infection induced PTEN overexpression and this leads to suppression of antibody response.

Suppression is seen with viral infection but not for bacterial ininfection because B cells are more adapted for bacterial infection than that of viral infection.

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