Questions based on article below: https://medicalxpress.com/news/2017-11-capsule
ID: 210627 • Letter: Q
Question
Questions based on article below: https://medicalxpress.com/news/2017-11-capsule-paves-simpler-difficile-treatment.html
1. Why did antibiotic therapy fail to treat Karen Shandro's c.difficile infection?
2. Desscribe the FMT therapy that was used to successfully treat Ms. Shandro's C.difficle infection. Explaine 1. the basic premise of the therapy ( why it works). 2. how the treatment was prepared 3. how the treatment was administered
3. what advantages does FMT provide, compared with traditional antibiotic therapy for C.difficile infections? (why do patient choose this new therapy) What challenges may be associated with MFT? (why might a patient be disinclined to try it) based on the reading, would you be inclined to request FMT as a first line treatment for a C.difficile infection?
Explanation / Answer
C.difficile is resistant to antibiotic treatment, infant it helps to disrupt gut microflora and give an opportunity to opportunistic bacteria and c.difficile to move in and cause illness.
the basic premise of the therapy -FMT (fecal microbiota transplant) increases the diversity of intestinal flora which alters the currently activated metabolic pathways and helps in controlling C.difficile.
how the treatment was prepared- The Faecal material o the healthy donor.
how the treatment was administered-colonoscopy or by swallowing capsules but Ms. Shandro's took this treatment orally.
The advantages associated with FMT - as traditional antibiotic therapy directly inhibit the growth of gut microflora which is harmful for the patient, but in fact, it helps C.difficile to cause illness. However, FMT does not inhibit gut flora but it increases the diversity of MO's in gut flora.
why might a patient be disinclined to try it-unpleasant taste or aftertaste to the pills or sanitation issues linked to the manipulation of fecal matter
Modified Fecal Transplantation (MFT)
would you be inclined to request FMT as a first line treatment for a C.difficile infection- A treatment in capsule form would also represent a more pleasant readymade solution for patients, who would not have to go through several weeks of suffering before being offered it as a last resort solution. Because of that, it would be considered as a first-line treatment for a C.difficile infection.
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