ezto.mheducation.com Chapter 7 Sections 1-6 0.74 points Gene mutation results Cl
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ezto.mheducation.com Chapter 7 Sections 1-6 0.74 points Gene mutation results Classify the likely effect of each mutation. Longer protein No change to protein No protein produced Insertion of 6 bases in the second exon Point mutation in stop codon Insertion of 9 bases in the second intron Deletion of 3 bases in the second intron Protein of same size with different sequence Shorter protein Insertion of 5 bases in exon #1 and deletion of 5 bases in exon #2 Deletion of 12 bases in the second exon Point mutation in start 2 3 4 9 IA/Explanation / Answer
Insertion of 6 bases in the second exon: Longer proten (Exon is the coding region of gene and insertion of bases will code for extra 2 amino acids; 3 bases constitute one codon which code for a single amino acid.)
Point mutation in stop codon: Longer protein (Stop codon is responsible for termination of protein synthesis. A point mutation in stop codon will stop the termination of protein synthesis till the next stop codon comes on reading frame and thus, longer protein will be produced. Point mutation is substitution of single base).
Insertion of 9 bases in the second intron: No change to protein (Introns are the non coding region of gene which are spliced off later and thus change in introns does not affect the protein).
Deletion of 3 bases in the second intron: No change to proten (Introns are non coding reason)
Insertion of 5 bases in exon 1 and deletion of 5 bases in the second exon: Protein of same size with different sequence (Insertion or deletion of 5 bases will change the whole reading frame because codons are triplet thus, the sequence of amino acid in protein will be changed and since same number of bases are inserted and deleted therefore, the size of protein will be same)
Point mutation in start codon: No protein produced (Start codon is responsible to start the protein synthesis and a point mutation will cause no initiation of protein synthesis).
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