Why do enzymes that lie downstream of a cell surface receptor in a signal transd

Question

Why do enzymes that lie downstream of a cell surface receptor in a signal transduction pathway amplify as well as propagate the signal? As a cell biologist for a pharmaceutical company, you are charged with developing a drug to inhibit the cAMP-cAMP response element binding protein (CREB) pathway Briefly describe the cascade leading to CREB activation and where one might target a drug to block its activation. What are the hallmarks of the first steps in signaling through receptor protein- tyrosine kinases?

Explanation / Answer

What are the hallmarks of the first steps in signaling through receptor protein-tyrosine kinases?
Ans-
Receptor protein-tyrosine kinases are synthesized as single-pass transmembrane proteins and bind polypeptide ligands. They are activated by ligand-induced dimerization of the receptors that phosphorylated their intracellular substrates to change their shape and function of the target proteins. These proteins kinases consist of protein interaction domains that arrange the signal protein complexes on the inner surface of plasma membrane.

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