5. For each of the following cell components or processes, indicate whether it i

Question

5. For each of the following cell components or processes, indicate whether it is involved in the processing and presentation of extracellular Ags (E), cytosolic Ags (C), both (B) or neither (N). Do not consider Ag cross- presentation or autophagy. Circle the correct answer. (10 pts) a. MHC class l b. MHC class ll c. B2 microglobulin d. Calnexin e. TAP 1/2 f. Immunoproteasome g. Invariant chain h. Endoplasmic reticulum I. Tapasin j. HLA-DR E C B N E C B N E C B N E C B N E C B N E C B N E C B N E C BN E C B N E C B N

Explanation / Answer

Answer:

a, MHC class I - C (involved in processing and presentation of endogenous or cytosolic antigens)

b. MHC class II - E (involved in processing and presentation of exoogenous or extracellular antigens)

c. Beta 2 microgobulin - C ( part of MHC I molecule)

d Calnexin - C ( participate in assembly of MHC I molecule)

e. TAP 1/2 - C (Involved in transpotation of antigen to ER lumen from cytosol)

f. Immunoprteosome - C ( participate in processing of cytosolic antigens)

g. Invariant chain - E ( part of MHC II molecule)

h. Endoplasmic reticulum - B (Processs the presention of both through MHC I and MHC II molecule)

i. Tapsin - C ( participate in assembly of MHC I molecule)

j. HLA-DR - E ( participate in assembly of antigen paptide at MHC II molecule)

Related Questions

Navigate

• Browse (All)
• Browse 5
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.