2. For each of the statements below (a-g) circle the correct choice, TRUE or FAL

Question

2. For each of the statements below (a-g) circle the correct choice, TRUE or FALSE. If the statement is FALSE, correct the statement with new information. Do not simply negate the statement or change the focus of the sentence. (14 pts) a. TRUE or FALSE: The mechanism that shifts membrane lg to a secreted form involves DNA rearrangement b. TRUE or FALSE: Antigens are the same thing as immunogens c. TRUE or FALSE: An epitope is the part of an antibody that physically contacts an antigen d. TRUE or FALSE: Kappa light chains are always present in lgM, IgD and lgG isotypes, whereas lambda light chains are always present in lgA and lgE e. TRUE or FALSE: In generating a productive IgH gene, VH segments generally do not directly join to JH segments because of the 12/23 rule. f. TRUE or FALSE: The chemical bonds that hold an antibody to an antigen are both covalent and non-covalent g. TRUE or FALSE: The mechanism that enables co-expression of membrane lM and membrane laD involves somatic recombination

Explanation / Answer

A)True

B) False. Immunogen is the molecule which can evoke an immune response. Whereas Ag is the molecule which can bind with the antibody (which is the resultant product of that immune response). So, all immunogens are antigen as they are capable of evoking immune response. But only antigen can bind to Ab.

C) False. Epitope is the part of ANTIGEN. Antibody binds with the antibody at the epitope region of that antibody.

F) False. Bonds must be non covalent.

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