10. Whippets are a breed of racing dog. Whippets that are homozygous for a two b

Question

10. Whippets are a breed of racing dog. Whippets that are homozygous for a two base-pair recessive mutation in the myostatin gene have huge muscles and are called "bulky Heterozygotes are strong racers. This mutation impairs the ability to synthesize myostatin by a. keeping ribosomes away from mRNA. b. altering the reading frame. e. keeping tRNAs away from mRNA. d. killing stem cells. e. dismantling replication forks. QUESTIONS FOR RESEARCH AND DISCUSSION I1. Explain why all known myostatin mutations that cause double muscling are nonsynonymous (change the encoded amino acid sequence) rather than synonymous (do not change the amino acid sequence). 12. Do you think that someone who is extra strong due to a myostatin mutation should be considered to have an unfair advantage in athletic competition? 13. Suggest a medical treatment that would involve the use of myostatin.

Explanation / Answer

Ans. The mutation impairs the ability to synthesis myosin by altering the reading frame.

Option b

A 2 bp deletion in the whippet MSTN gene in the homozygote state results in double muscling phenotype which are commonly known as bully whippet this alteration results in premature truncation of protein at amino acid 313 resulting in 17 % less protein synthesis.

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