e All of the above 12) Allolio exclusion occurs in a dendritio cells b macrophag
ID: 209579 • Letter: E
Question
e All of the above 12) Allolio exclusion occurs in a dendritio cells b macrophages 6. B cells d Antigen presenting cells e All of the above 13) True or false? MHC class il prohoins toined onity to non-t pepices a True b. False 14) MHC class Ii molecules are expressed on a. all nucleated cells b. T cells only o B cells only d. APCs 15) MHC class II proteins do not usually take up peptides in the rER because a. the rER contains no class II binding peptides b. class II proteins are degraded in the rER c. c. class II proteins are not translated in the rER d. class II proteins are coexpressed with an invariant chain (i) that blocks peptide binding 16) MHC class II proteins are usually loaded with peptides in: a. the rER b. the endosome c. the plasma membrane d. the GolgiExplanation / Answer
Answer:
12. Allelic exclusion occurs in B cells (option c). Allelic exclusion in the process of expression of one allele of gene and silencing of another allele. This takes place in B cells which is the genetic rearrangement from one chromosome and shutting down the rearrangement in another chromosome.
13. True (option a) MHC class II antigens are mainly concerned with extracellular pathogen proteins.
14. MHC class II molecules are constitutively expressed by immune APCs (option d).
15. MHC class II molecules do not usually take up peptides in rER because class II proteins are coexpressed by with an invariant chain that blocks peptide binding (option d).
16. MHC class II molecules are usually loaded with proteins in the golgi (option d) wherein there is breakage of invariant chain.
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