Questions 4-5: In eukaryotes, miR-5 is a microRNA with sequence complementarity
ID: 209533 • Letter: Q
Question
Questions 4-5: In eukaryotes, miR-5 is a microRNA with sequence complementarity to the 3’UTR of the mRNA transcript encoded by the BIS gene. The BIS gene encodes for a protein that acts as an allosteric inhibitor of the protein p101. The p101 protein is a DNA methyltransferase (DNMT) that functions to methylate DNA.
4. (2pts) In a breast cancer cell line, the p101 protein is active leading to misregulation of gene expression. In these breast cancer cells which of the following would be a correct prediction in regards to miR-5? (choose all that apply)
The gene encoding miR-5 is in a region of chromatin with hypoacetylation
The gene encoding miR-5 is in a region of chromatin with hyperacetylation
The gene encoding miR-5 in a region of euchromatin
The gene encoding miR-5 in a region of heterochromatin
The miR-5 transcript is translated at high levels
The miR-5 transcript is activating translation of the BIS gene
The gene encoding miR-5 is in a region of chromatin with hypoacetylation
Explanation / Answer
DNMT1 (DNA Methyltransferase 1) is a Protein Coding quality. Infections related with DNMT1 incorporate Neuropathy, Hereditary Sensory, Type Ie and Cerebellar Ataxia, Deafness, And Narcolepsy, Autosomal Dominant. Among its related pathways are Macrophage Differentiation and Growth Inhibition by METS and Cytosine methylation. GO comments identified with this quality incorporate RNA authoritative and translation factor official. This quality encodes a protein that exchanges methyl gatherings to cytosine nucleotides of genomic DNA. This protein is the significant catalyst in charge of keeping up methylation designs following DNA replication and demonstrates an inclination for hemi-methylated DNA. Methylation of DNA is a critical segment of mammalian epigenetic quality control. Deviant methylation designs are found in human tumors and related with formative variations from the norm. Variety in this quality has been related with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, inherited tangible, type IE. Elective grafting brings about various transcript variations
The statement of hereditary data inside an individual cell directs how that cell in this way acts. Occasions at the atomic level can impact the outflow of specific qualities and in this way antagonistically influence cell capacity enough to start a pathologic procedure. Disease cells, for instance, must experience various sub-atomic occasions that enable them to secure a few particular yet pathologic behavioral properties. These properties result in malicious clinical outcomes for the patient in whom the growth cell dwells, yet incomprehensibly enables that unusual cell and its descendants with a survival advantage over typical cells.
Nanocapsules of poly(methyl methacrylate) (Nc-PMMA), when related with different particles can advance a controlled medication discharge and enhance the take-up productivity by the objective. Along these lines, this investigation intended to fuse the common compound -terpineol (-Tp) into Nc-PMMA and further assess its cytotoxic potential.
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