10. (2pts) (Circle the to an INCREASE swers.) Repolarization of the membrane pot
ID: 209411 • Letter: 1
Question
10. (2pts) (Circle the to an INCREASE swers.) Repolarization of the membrane potential is due ASE in the permeability of the membrane to Na, and an /DECREASE in the permeability of the membrane to K 11. (2pts) Excitatory neurotransmitters are most likely to open -gated a_channels on the post synaptic cell. asi ng the extracellular concentration of Na had very little effect on the membrane potential. Why not? 13. (3pts) What are 2 mechanisms used by the drugs we discussed in class for artificially increasing the amount of a particular neurotransmitter in the synaptic cleft?Explanation / Answer
10- Decrease in Na permeability and increase in K permeability.
11- Ligand gated Na channels.
12- Directly increasing the Na concentration has not much effect since the channel is ligand gated. First a ligand has to bind and that would open up the channel directly increasing the permeability of the channel.
12- Two ways by which neurotransmitter is increased in the cleft :
By inhibhiting the enzymes degrading the neurotransmitter and then increasing its concentration.
Second way is increasing the release of the transmitter from the pre synaptic end either by opening the calcium.channels or by displacing the neurotrasmitters from their vesicles.
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