can you please help me with this problem? I need to come up with 2 mechanisms ho
ID: 209218 • Letter: C
Question
can you please help me with this problem? I need to come up with 2 mechanisms how a cell could regulate and maintain the given ATP level thank you!
The proper cellular ATP levels are critical for almost all cell function (~1mM in the cytoplasm). In this problem set you will propose different mechanisms how a cell could regulate and maintain this ATP level. Your proposed mechanisms don't have to exist (do not read up online about the way cells regulate ATP levels!). But the mechanisms should be plausible and based on what you learned in the lectures about ATP, regulatory mechanisms and mitochondrial metabolism. All regulatory systems you need first a sensor that can identify a drop in ATP levels. Second you need an "executioner" that can receive the information from the sensor ahd execute a change to stabilize ATP levels. In your answers both describe briefly the mechanism and draw your proposed system. Your answers cannot include regulation of the ATP synthase or the electron transport chain (no direct regulation or changes in expression). These proteins are known to be highly stable and unlikely to be regulated. Sensor:Propose 2 different mechanisms that could be used to detect a drop in cellular ATP levels. Executioner 1) Propose one regulatory response that could lead to an increase in ATP synthesis (do not target ATP synthase of electron transport chain!), which stabilizes ATP levels 2) Propose one regulatory response that would lead to a drop in ATP consumption and thereby stabilizes the cellular ATP levels. It would be a good idea to think about which cellular pathways use the most energy (google might help) Regulatory system: Based on your proposed sensors/executioners draw two regulatory systems that combines one of your sensors with one of the executioners. Pick one sensor and connect it to one of your executioners. Then take the other sensor and connect it to the remaining executioner. Make sure your drawing explains how the sensor talks to the executioner. Also determine an estimated time the 2 regulatory systems would take to stabilize the cellular ATP levelsExplanation / Answer
Mechanism 1
The ATP production can be regulated and increased by the mitochondrial calcium. It helps in controlling cellular ATP homeostasis. The glycolytic mechanism generates 2 number of molecules, citrate cycle is responsible for production of 36 to 38 molecules and rest is produced by oxidation of NADH to FADH2. All of these reactions are tightly controlled by ATP synthesis.
Mechanism 2
There are many ways to boost or increase the production of the ATP. It is the energy currency of the body and It can be enhance by increasing creatinine concentration. It is an amino acid which is responsible for natural conversion of it into ATP. Also to enhance the production or concentration of ATP one can choose to consume 30 to 200 mg of coenzyme Q10. It helps in boosting energy level.
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