1. Which of the following is NOT true regarding IRE1? Binding of misfolded prote
ID: 209170 • Letter: 1
Question
1. Which of the following is NOT true regarding IRE1?
Binding of misfolded proteins activates IRE1 causing it to oligomerize
IRE1 is protein kinase located on the plasma membrane
IRE1 has two catalytic domains on its cytosolic side, a kinase domain and an RNase domain.
IRE1 activation generats a transcription regulator that triggers changes in gene expression
2. Which of the following is NOT true regarding the unfolded protein response?
It will result in a reduction of ubiquitination.
It will result in activation of chaperone genes.
It will result in activation of components of the ER-associated degradation (ERAD) machinery.
It will result in a reduction of proteins entering the ER.
Explanation / Answer
1. Option B is NOT true regarding IRE1.
Inositol-requiring enzyme 1 (IRE1) is an Endoplasmic reticulum transmembrane glycoprotein which is an essential component of the Unfolded Protein Response (UPR) pathway important for sensing and responding to cellular stress.
2. Option A is NOT true regarding unfolded protein response
A transcription factor called Hac1, binds to the promoter region of UPR-regulated genes and is more resistant to ubiquitin-dependent degradation
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