biochemistry A. FILL IN THE BLANKS, using the list of words/phrases below. (Each
ID: 209061 • Letter: B
Question
biochemistry
A. FILL IN THE BLANKS, using the list of words/phrases below. (Each word/phrase may be used more than once and some may not be used at all), In skeletal muscle setheis the immediate source of ATP during brief, but demanding, physical effort (such as weight-lifting) or during the first 20-40 metres of a sprint. Thereafter, carbohydrate metabolism becomes important. In medium-distance and long-distance events, in which oxygen is the preferred fuel of delivery may be a limitation, skeletal muscle as its oxidation produces the largest yield of ATP per mole of 02 consumed. When exercise is very vigorous, produced in muscle which is released from the muscle and becomes a substrate for gluconeogenesis. The principal function of glycolysis, in most tissues, is the production of ATP and, hence, it is regulated, directly or indirectly, by ATP levels. A crucial component of this regulatory mechanism is the activation of concentration ncsenses wen that of ATP falls a little. Another feature of this regulatory mechanism is the of bexokinase by is by AMP, whose Word/Phrase List for Ouestion A increases decreases remains unchanged inhibits activates inbibition activation repression recruitment fructose-1,6-Bis-P glucose glycogen fatty acids ketones amino acids phosphocreatine proton phosphate phosphorylation allosteric inhibition transport pyruvate lactate citrate glucose-6-P glucose-1-P glucokinase hexokinase phospbofructokinase-I phospbofructokinase-2 glycogen phosphorylase pyruvate dehydrogenaseExplanation / Answer
The following blanks are given below
1. phosphocreatine
2. fatty acids
3. lactate
4. phosphofructokinase-1
5. increases
6. inhibition
7. glucose-6-phosphate
Creatine phosphate or phosphocreatine, the high energy molecule, is the immediate source of energy in skeletal muscles. It provides phosphates to ADP molecules for the production of ATP. In the medium distance and long-distance events such as jogging, running, etc., fatty acid is the preferred fuel but as the intensity of exercise increases, lactic acid or lactate is produced in the muscle cells and is converted into glucose in the liver. Glycolysis is regulated by three enzymes: hexokinase, phosphofructokinase-1 and pyruvate kinase. Phosphofructokinase is inhibited by the high levels of ATP. When energy gets depleted, the concentration of AMP increases which gives a signal for the low-energy state. Hexokinase is allosterically inhibited by its product, glucose 6-phosphate. High concentrations of glucose 6-phosphate signal that the cell no longer requires glucose for energy. When phosphofructokinase is inactive, the concentration of fructose 6-phosphate increases. This, in turn, increases the concentration of glucose 6-phosphate because it is in equilibrium with fructose 6-phosphate. Thus, this regulatory mechanism, i.e., inhibition of phosphofructokinase leads to the inhibition of hexokinase.
Related Questions
Navigate
Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.