8. If you treated isolated mitochondria with an excess NADH and O2, but inhibite

Question

8. If you treated isolated mitochondria with an excess NADH and O2, but inhibited complex IV using cyanide, what would you predict? Choose any that apply. a. The intermembrane space would be more acidic than the matrix. b. The intermembrane space would more basic than the matrix. c. The intermembrane space pH will be the same as the matrix. d. ATP synthesis would occur continuously e. ATP synthesis would be reduced or stop altogether f. NADH would NOT be oxidized continuously by the electron transport chain g. NADH would be continuously oxidized by the electron transport chain

Explanation / Answer

Answer:

a. The intermembrane space would be more acidic than the matrix.

e. ATP synthesis would be reduced or stop altogether

f. NADH would NOT be oxidized continuously by the electron transport chain

Explanation:

Cyanide inhibits Complex IV, known as cytochrome oxidase, preventing the transfer of electrons to molecular oxygen. Cyanide prevents oxygen consumption, and because ATP production is also prevented, ATP synthesis must require electron transport.

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