Problem Set 2 Biology 401, Spring 2018 1. Poliovirus is a Group IV virus contain

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Problem Set 2 Biology 401, Spring 2018 1. Poliovirus is a Group IV virus containing a positive stranded RNA genome (Baltimore classification-see Fig 6.15) Influenza virus is a Group V virus and Human Immunodeficiency Virus (HIM) is a group these viruses binding, genome entry, synthesis of viral mRNA, translation of viral proteins, replication of new viral genomes, and packaging of genomes into progeny virions. The life cycle VI virus. Complete the table below for each of to include the order in which the following steps first occur: receptor Poliovirus Influenza HIV receptor binding genome entry synthesis of viral mRNA translation of viral proteins Synthesis of template for genomic and 2 MRNA 2. The genome of a newly discovered bacterial species (Bacillus sanfranciscus) is sequenced and found to have a circular genome of 4.1 x 10° base pairs (bp). Open reading frame (ORF) analysis indicated the presence of 3,558 ORFs that encode proteins with a median length of 270 amino acids (aa) and an average length of 360 aa. What us the information content of this genome (ie.-how much information can be encoded in this length of DNA)? Since the genetic code can be considered digital in nature, let's convert the information content of base pairs into bytes and compare this value with the information content of the operating system of a digital device many of us routinely use. Assume that the iPhone operating system requires approximately 2 GB of information to perform its functions. To compare the amount of information encoded in iOS8 and in the genome of B. sanfranciscus, the following assumptions about the digital content of DNA-encoded information might be helpful. The double helix can potentially encode information in both strands but this is not usually the case; most stretches of DNA encode information in only one strand (although for any given gene it can be either of the two strands). So, it is therefore reasonable to assume that each base pair of DNA encodes 2 bits of information (since there are 4 possible nucleotides). Keeping in mind that 1 byte = 8 bits and 1 GB = 10° bytes, the calculation is pretty straightforward from there. Express your answer as iPhone ios units (ie,-1 ios unit = 2GB). a. b. Now calculate the percentage of the bacterial genome that encodes the cell's complete proteome. Assume that: a) all of the predicted ORFs actually encode proteins, b) each gene is encoded by only one of the two strands of DNA, and c)

Explanation / Answer

Poliovirus Influenza HIV receptor binding 1 1 1 genome entry 2 2 2 synthesis of viral mRNA 3 3 4 translation of viral protein 6 5 5 synthesis of template for genomic and mRNA 4 and 5 4 3 packaging of genome into progeny virions 7 6 6

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