Steps 1,3 and 10 are regulation points for glycolysis. Suggest a reason why step

Question

Steps 1,3 and 10 are regulation points for glycolysis. Suggest a reason why step #3 or PFK is the principle control point for the pathway. 4. 5. Gluconeogenesis converts pyruvate to glucose and is the reverse of glycolysis. a. How many steps occur in gluconeogenesis? b. Many of the enzymes used in each pathway are the same. Explain how the sign of Gibbs free energy can change so a reaction is spontaneous in both direction c. Write the net reaction equation for gluconeogenesis. O d. Under what physiologic conditions would gluconeogenesis be activated. a. Briefly describe the Cori cycle. b. In which tissue does the anabolic phase occur. c. Can the cycle be run indefinitely? Explain. 6.

Explanation / Answer

Phosphofructokinase, PFK is a ke regulatory enzyme in regulating glycolysis. It catalyzes an important reaction in glycolysis, which makes the pathway committed. It catalyzes the conversion of fructose-6-phosphate and ATP to fructose 1-6 bisphosphate and ADP. This is a key regulating step in glycolysis.

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