Using the diagram of the synaptic inputs below, assume E1 and E2 release the sam

Question

Using the diagram of the synaptic inputs below, assume E1 and E2 release the same amount of neurotransmitter and that the same number of receptors are located on the synaptic membrane for both of these synapses. Alone, neither causes an action potential, but together they can if they occur within 2ms of eachother. Stimulation of I can prevent an action potential if it occurs within 1ms of an excitatory pulse. 3. xcitatory (EI Inhibitory t) Excitatory (EZ) Postsyna membran potential Theeshold- Cell body Dendritis 01234023 Time (ml Axon a. What kinds of ion channels are likely opened by E and I, explain your answer

Explanation / Answer

Glutamate receptors are synaptic receptors on neuronal membrane.it is the main excitatory neurotransmitter and also the mainprecursor for GABA , the brain's main inhibitory nerotransmitter.

Ionotropic glutamate receptors form the ion channel pore which is activated when glutamate binds to the receptor.Ionotropic glutamate receptors are ligand gated non selective cation channels which allow the flow of potassium sodium and sometimes calcium upon binding stimulates direct action of the central pore of the receptor and allows ion flow causing depolarisation and excitatory post synaptic current (EPSP)

GABA ( gamma amino butyric acid ) is an ionotropic receptor and ligand gated anion channel which is endogenous. it is the major inhibitory neurotransmittor,

Upon activation this receptor selectively conducts chloride ions through its pore resulting in hyperpolarisation of the neuron and causes inhibitory effect on neurotransmission.

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