The catabolism of heme from erythrocytes occurs principally in the spleen & live

Question

The catabolism of heme from erythrocytes occurs principally in the spleen & liver where the heme is broken down by an axygenase and reductase to form bilirubin. Bilirubin is converted via UDP-glucuronosyl transferase to the product seen below. Which of the following may be th reason for this last step? C increase solubility in HO so it can be excreted C conversion to amino acids precursors C provide free energy needed for reforming a heme group C increase likellhood it will be metabolized by glycolytic enzymes c preparatory step for aminolevulinate dehydratase activity

Explanation / Answer

Answer - increase solubility in H2O so it can be excreted.

Bilirubin diglucuronide is a hydrophilic character enables it to be water-soluble.

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