Imagine you are a drug developer aiming to inhibit G-protein coupled receptor si

Question

Imagine you are a drug developer aiming to inhibit G-protein coupled receptor signal transduction specifically in liver cells. An inhibitor of which of the following would accomplish this? A. kinase activity B. cAMP Phosphodiesterase activity (remember cAMP PDE breaks down cAMP) C. Phosphatase activity D. GTPase activity Imagine you are a drug developer aiming to inhibit G-protein coupled receptor signal transduction specifically in liver cells. An inhibitor of which of the following would accomplish this? A. kinase activity B. cAMP Phosphodiesterase activity (remember cAMP PDE breaks down cAMP) C. Phosphatase activity D. GTPase activity A. kinase activity B. cAMP Phosphodiesterase activity (remember cAMP PDE breaks down cAMP) C. Phosphatase activity D. GTPase activity

Explanation / Answer

B. cAMP Phosphodiesterase activity

cAMP phosphodiesterase can break down cAMP which acts as secondary messengers in the G-protein coupled receptor signal transduction. When the G protein-coupled receptor present in the membrane of the liver cells are activated, it stimulates the enzyme adenyl cyclase which catalyzes ATP to form cAMP. cAMP, in turn, activates protein kinase A to show the required biological effects. Thus, these signals then can be inhibited by cAMP phosphodiesterase, which is an enzyme that degrades cAMP.

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