You\'ve been doing some genetic analysis regarding the MTRC gene; a novel mutati

Question

You've been doing some genetic analysis regarding the MTRC gene; a novel mutation in this particular gene leads to some really strange outcomes in your yeast. You've noticed that every subsequent generation of this genetically-engineered mutant yeast seems to have novel lack of function issues. Like, your first generation of this mutant completely lacks lactose transporter proteins. The second generation do not have any glucose receptors. And the third generation is unable to generate pyruvate. You've replicated these results numerous times and yet every time you generate the MTRC mutant in yeast, each generation effectively loses the ability to make these proteins. Other than these specific issues (and whatever happens as a result of these issues), your yeast are otherwise normal and fine. Based on all of this information, which protein important for DNA replication do you think this MTRC gene impacts?

telomerase

primase

initiation proteins

DNA pol I

single stranded binding proteins

DNA pol III

helicase

ligase

topoisomerase

Explanation / Answer

Answer : Telomerase. Because, in each generation, a particular receptor or enzyme essential for metabolism of lactose is not synthesized due to telomere end reduction.

Telomerase : It is an enzyme which adds specific repeat sequences at the 3'end of the telomere in order to extent the chromosome length after each replication.

Primase : It is an enzyme which synthesizes short RNA sequences as primers which helps to initiate DNA replication.

Ligase : It is an enzyme which helps to join DNA fragments. Okazaki fragments synthesized during DNA replication are joined by ligase.

Topoisomerase : It is an enzyme which helps to underwind or overwind the DNA. During DNA replication, DNA overwounds so, to protect torsion or topological problems, phosphate backbone is cut to complete DNA replication.

Helicase : It is an enzyme which unwinds DNA during replication in order to separate two strands.

Single stranded binding proteins : It binds to DNA during replication in order to stabilize the strands so that replication is faster.

DNA polymerase I : Fills the gaps that occurs during DNA replication

DNA polymerase III : Performs polymerase activity during DNA replication that is it adds nucleotides at the 3'end

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