If a portion of a chromosome is replicated more than once per cell cycle, ______

Question

If a portion of a chromosome is replicated more than once per cell cycle, __________; if a portion of a chromosome is replicated less than once per cell cycle, ___________.

A. there will be a gene amplification event/ the chromosome will break during metaphase

B. the chromosome will break during metaphase/ there will be a gene amplification event

C. the cell will transform to a tumor cell/ there will be an apoptotic cell death

D. there will be apoptotic cell death/ the cell will transform to a tumor cell

Explanation / Answer

If a portion of a chromosome is replicated more than once per cell cycle, there will be a gene amplification event; if a portion of a chromosome is replicated less than once per cell cycle, the chromosome will break during metaphase.

Replication of chromosome, more than once per cycle leads to increse in chromosome content thus leading to gene amplification event. Replication of chromosome less than once per cycle leads to breakage of chromosome during metaphase beacuse in normal conditon half chromosomes goes to one side and other half sets on other side of metaphase plate but there is only one chromosome so it can be broken down during this movement.

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