1. Whyis the NMDA pathway a potentially goodtarget for developing drugs for chro

Question

1. Whyis the NMDA pathway a potentially goodtarget for developing drugs for chronic or neuropathicpain or other indications? Glutamate is a key excitatory neurotransmitter in pain signaling. It can bind and activate NMDA receptors Compounds activating glutamate NMDA receptors have been shown to be effective in preclinical and clinical studies The balance of glutamate signaling through NMDA synaptic and extra-synaptic receptors promotes cell death Some compounds inhibiting specifically in the NMDA receptor 28 (extrasynaptic pathway) have a. b. c. d. been shown to have more side effects than those acting at the extracellularreceptor All of the above are correct e.

Explanation / Answer

the correct answer for the above question is->all of the above are correct that is option e

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