5A )Which of the following is required for canonical regulated protein degradati

ID: 206896 • Letter: 5

Question

5A )Which of the following is required for canonical regulated protein degradation?

1. E1 ubiquitin ligase

2. proteasome

3. E2 ubiquitin ligase

4. E3 ubiquitin ligase

5. ubiquitin

A) 1, 2, 3, and 5

B) 1, 3, 4, and 5

C) 1, 2, and 3

D) 1, 2, 3, 4 and 5

5 B) Which of the following is true about proteasomal degradation?

The 20S core of the proteasome is responsible for substrate recognition prior to degradation.

Monoubiquitination is a signal for proteasomal degradation.

Protein degradation is regulated by a balance between ubiquitin conjugation and deubiquitination.

Degradation specificity is conferred by the E1 ubiquitin ligase.

Which of the following is required for canonical regulated Protein degradation?

E1 ubiquitin ligase, E2Ubiquitin ligase, E3 Ubiquitin ligase, proteome

Which of the following is true about proteosomal degradation?

Protein degradation is regulated by a balance between ubiquitin conjugation and deubiquitination.

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