Which of the following statements is correct concerning the fate of double posit

Question

Which of the following statements is correct concerning the fate of double positive cells during selection in the thymus? A. Interaction with nonlymphoid thymic cells has no effect on double positive cell fate. B. double positive cells that have a high affinity reaction with thymic epithelial cells are positively selected and allowed to leave the thymus. C. double positive cells that have a high affinity reaction with thymic epithelial cells are negatively selected and destroyed. D. double positive cells that have an intermediate affinity reaction with thynic epithelial cells are negatively selected and destroyed.

Explanation / Answer

Answer: Option C is correct.

Explanation:

Double positive cells express both CD4 and CD8 co-receptors. They undergo positive selection to determine whether they can recognize self MHC molecule. They undergo negative selection if they bind too strongly to MHC presented self-antigens.

Hence, Double positive cells that have a high-affinity reaction with thymic epithelial cells are negatively selected and destroyed.

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