when both copies of an anti-oncogene have been inactivatect h when one copy of a
ID: 206193 • Letter: W
Question
when both copies of an anti-oncogene have been inactivatect h when one copy of an anti-oncogene is inactivated but the other e when both copies of an anti-oncogene are not active, but neu by mutations B. What is nullaygous? not due to a mutation, rather the antioncogenes are not needed in the d when both copies of a anti-oncogene are active and overpro e. none of the above s are not needed in the cell at a t the tetrameric protein? a. A mutation in only one of the p53 anti-oncogene alleles does a. Why does a mutation in only one p53 anti-oncogene allele cause 18 defect in the protein. b. Because p53 is expressed from both alleles and one mutant copy causen c. Because only one p53 allele is active at any given time d. Because each allele is expressed, making both good a half of the tetramer to be defective king both good and bad p53 proteins to assemble into mixed tetramers. e. none of the above er? a. inactivation of both copies of the DCC anti-on b. activation of the Ras oncogene c. mutation in one copy of the p53 gene d. inactivation of both copies of the APC anti-oncogene e. all of the above 13. Which of the following is a mutation associated with colon canc cogene 20 24. Which of the following inherited defects predisposes a person to a. DNA repair systems b. anti-oncogenes .components of DNA replication d. genetic differences between races (e.g., skin color and melanomal e. all of the above 15. How is a virus made oncolytic? a. by integrating the genes for tumor-suppressor and necrosis factors into the viral genome under a constitutive promoter b. by changing the location of a viral DNA integration into the host cell so that it causes a gene knockout in the defective gene that is causing the cance c. changing the viral protein that binds to the host cells so that it only recog- Furth Balmaña in breast Blanpain Chen, P S Frazer, I hroughi Carraway nizes and infects, then kills, cancer cells d. by cloning genes for apoptosis into the viral genome, which integrates into the host cancer cells and kills the cells e. none of the above 16. The result of inhibiting PARP is all of the following except a. an accumulation of double-strand breaks in the DNA b. inhibition of base excision repair pathways c. cell death d. activation of p53 e. lack of poly(ADP-ribose) chains being added to single- and do Hilton. I breaks 21(8), 43Explanation / Answer
11.
Incorrect: when one copy of anti-oncogene is inactivated but the other is still active is the condition which, is called as hemizygous but not nullizygous.
When both the copies of anti-oncogene are active and overproducing the protein is the condition due to dominantly active oncogenes. This condition is not called as nullizygous.
Hence options (b), (c), (d), and (e) are incorrect.
Correct: when both of the anti-oncogene have been inactivated by the mutation is called as nullizygous. Nullizygous refers to an organism carrying two loss-of function alleles for the same gene.
Hence, the correct option is (a).
Related Questions
Navigate
Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.