My project name First about the \'normal protein: 1. What is the cellular enviro
ID: 205833 • Letter: M
Question
My project name First about the 'normal protein: 1. What is the cellular environment? 2 What does it do? Is anything known about the amino acids involved in its function? (Such information could be based on mutational studies or structural studies) 3 What protein family does it belong to? (Gives you functional information.) 4. Are any post-translational modifications expected? Then about the particular amino acid which is variant: 5. Is the position conserved across orthologues, and or paralogues? (suggest importance of the amino acid to the protein's function) 6. Where does the amino acid occur in the secondary structure? Could the mutation affect the secondary structure? 7.Is the amino acid involved in protein function? For example is it part of an active site and might it make contacts with a substrate? 8. If the structure of the protein or a closely related protein has been resolved, what does it tell you about the function of the normal amino acid in the proteins Then questions about the project in general: 9. What is the official Gene symbol? 10. What is the gene name? 11. What is the GenelD number? 12 Where in the human genome is this gene located? 3. What is the function of the protein? (For example: enzyme, structural, cell signaling etc. - a protein may have more than one function) 14. What specific role does it play in the cell? (For example: if an enzyme, what type and what reaction does it catalyze, if structural, what structure.) 15. What is the RefSeq accession number for the mRNA of this gene? 16. What is the RefSeq accession number for the protein sequence (is it the product of the gene)? 17. What is the SwissProt accession number? (Hint: for proteins it always starts with a P) 18. What are the alternate names for this protein? 19. Where in the cell is this protein located? (If it is known it will be in the comments if it is not listed your answer is·unknown".)Explanation / Answer
1. Super oxide dismutase have very stressful environment as it is a vital anti-oxidant defence in every cells.
2. Protein catalyses the dismutation of superoxide radical. Asn-89, is one amino acid involve in its function.
3. Superoxide dismutase gene family.
4. Yes, post-translational modification is expected.
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