An individual bears a dominant mutation that leads to dramatic increase in nondi

Question

An individual bears a dominant mutation that leads to dramatic increase in nondisjunction of all chromosomes during meiosis. this person, perhaps not surprisingly, displays reduced fertility, manifested as an increase in early miscarriage. what probably explains this subfertility?

1. high levels of aneuploidy among their progeny.

2. Increased movement of transposons in their gametes.

3. production of dicentric bridges and loss of acentric chromosome

4. Heterozygosity for a balanced translocation.

Explanation / Answer

Option 1 is correct.

Non-disjunction of all chromosomes during meiosis results in high levels of aneuploidy among their progeny. Chromosomal aneuploidy is the leading cause of pregnancy loss and developmental disabilities in humans. Aneuploidy is predominantly maternal in origin, but concerns have been raised regarding the safety of intracytoplasmic sperm injection as infertile men have significantly higher levels of sperm aneuploidy compared to their fertile counterparts. Males with numerical or structural karyotype abnormalities are also at an increased risk of producing aneuploid sperm. Chromosomal aneuploidy is a result of a meiotic non-disjunction event in gametes, thus the most probable cause of subfertility can be high levels of aneuploidy among their progeny.

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