Read the following abstract \"Despite decades of effort, little progress has bee

Question

Read the following abstract

"Despite decades of effort, little progress has been made to improve the treatment of cancer metastases. To leverage the central role of the mechanoenvironment in cancer metastasis, we present a mechanoresponsive cell system (MRCS) to selectively identify and treat cancer metastases by targeting the specific biophysical cues in the tumor niche in vivo. Our MRCS uses mechanosensitive promoter–driven mesenchymal stem cell (MSC)–based vectors, which selectively home to and target cancer metastases in response to specific mechanical cues to deliver therapeutics to effectively kill cancer cells, as demonstrated in a metastatic breast cancer mouse model. Our data suggest a strong correlation between collagen cross-linking and increased tissue stiffness at the metastatic sites, where our MRCS is specifically activated by the specific cancer–associated mechano-cues. MRCS has markedly reduced deleterious effects compared to MSCs constitutively expressing therapeutics. MRCS indicates that biophysical cues, specifically matrix stiffness, are appealing targets for cancer treatment due to their long persistence in the body (measured in years), making them refractory to the development of resistance to treatment. Our MRCS can serve as a platform for future diagnostics and therapies targeting aberrant tissue stiffness in conditions such as cancer and fibrotic diseases, and it should help to elucidate mechanobiology and reveal what cells “feel” in the microenvironment in vivo."

Write an in depth question (do not answer it) to the author of this abstract concerning the subject matter.

Explanation / Answer

Ans:- What are those specific biophysical cues other than matrix stiffness? whether these cues are restricted to diseased cells only ? What is mechanism behind activation of MRCS by biophysical cues?Why do you particularly choose mesenchymal stem cell vector? What can be its side effect on body? What is signalling behind action of MRCS that makes effective delivery of therapeutics inside cells? Does it interferes in transcription regulation of any genes, if yes which genes?

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