Neeed help with cell bio lab Adipogenesis 1.566 (group 12) 1.388 (group 5) 0.644

Question

Neeed help with cell bio lab Adipogenesis

1.566 (group 12)

1.388 (group 5)

0.644 (group 11)

0.94 (group 10)

1.16 (group 1)

1.68 (group 2)

1.806 (group 9)

1.48 (group 9)

1.88 (group 6)

3.42 (group 8)

1.038 (group 3)

1.) How does insulin concentration affect adipogenesis? i.e. How did the data from your group turn out, how did your data compare against the class data, and what do you interpret from the overall picture of the data?

2.) How would you expect chronically high levels of insulin and glucose to affect adipogenesis?

3.) How is adipogenesis related to obesity?

4.) Create a hypothesis: Would you expect brown adipocytes to respond the same way that white adipocytes do to insulin and glucose? Why or why not?

FINAL QUESTION BELOW ALSO PLEASE!

1) Approach: Create a summary of the overall approach you use to answer the question being addressed.

Diffrent concentrations 0 0.25 1 4 R1

1.566 (group 12)

1.388 (group 5)

0.644 (group 11)

0.94 (group 10)

R2

1.16 (group 1)

1.68 (group 2)

1.806 (group 9)

1.48 (group 9)

R3

1.88 (group 6)

3.42 (group 8)

1.038 (group 3)

Average 1.535 1.534 1.95 1.152

Explanation / Answer

1) Adipogenesis is the development of fully differentiated mature lipid filled adipocytes from precursor cells, pre-adipocytes. Insulin is an adipogenic hormone that stimulates the differentiation of pre-adipocytes to mature lipid filled adipocytes. Insulin restricts the formation of glucose or lowers blood glucose level and inturn increases lipid synthesis, lipogenesis, which is stored in the adipocyte. Therefore adipogenesis is directly affected by insulin or in other words, insulin is required for the differentiation od pre-adipocytes to mature adipocyte cells.

2) With the intake of carbohydrate rich food, insulin production increases to maintain the blood glucose level by stimulating adipogenesis. Chronically high level of glucose intake increases high insulin production and increases the formation of free fatty acid until glucose level is controlled or insulin resistance begins.

3) Adipogenesis leads to the storage of fats in adipose tissue, formation of large number of adipocytes with increased size. An increase in the number of adipocytes causes white adipose tissue (WAT) to expand that leads to obesity (the accumulation of fat in the body)

4) White adipocytes contain single droplet of lipid. WAT is insulin sensitive and thereby stores fat as triglyceride that inturn leads to obesity.

Brown adipocytes contain numerous small droplets of fat as well as large number of mitochondria, the reason for the brown color of adipocyte. These fat droplets are used for production of energy hence are 'good fats'

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