You are provided with the following information about a new receptor protein des

Question

You are provided with the following information about a new receptor protein designated p15:

p15 is an integral membrane protein

the complete amino acid sequence of p15 contains 7 putative transmembrane domains

agonist-stimulation of p15 receptor-expressing cell lines results in decreases in forskolin-induced increases in cAMP accumulation and is dependent on a heterotrimeric G protein.

Which of the following actions which occur in response to binding of an agonist to a GPCR like 15, can be mediated by beta-arrestin:

You may choose more than one answer.

Explain both why you made your choices and why you did not select the others.

a) direct inhibition of GTPase activation

b) internalization of the GPCR via clathrin-coated pits

c) activation of protein kinases via scaffold function of beta-arrestins

d) phosphorylation of GPCR

Explanation / Answer

b) Internalization of the GPCR via clathrin-coated pits.

Beta-arrestins target receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins).

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