28. Why did Jessie’s carnitine deficiency cause her to have abnormally low plasm

Question

28. Why did Jessie’s carnitine deficiency cause her to have abnormally low plasma glucose levels at the end of a fasting study, when compared to a healthy person who has fasted for the same length of time? A. In the absence of carnitine, the liver stores large amounts of glycogen; absorption of glucose to create these stores depletes blood glucose. B. Carnitine acts as a hormone and stimulates glucose release from the liver; lack of carnitine results in loss of hepatic glucose production, which leads to hypoglycemia. C. In the absence of carnitine, fatty acids cannot be used for energy nor can ketone bodies be produced in large quantities; tissues like the muscle, heart, and brain can only use glucose under these conditions. This drives excessive glucose uptake from the blood, depleting glycogen stores in the liver and resulting in hypoglycemia. D. In the absence of carnitine, fatty acid transport into the mitochondria requires a large amount of ATP; to produce the additional ATP required the liver must oxidize glucose, which depletes glycogen stores, causing hypoglycemia. E. In the absence of carnitine, Jessie’s muscles could not use fatty acids as substrates for glycolysis.

Explanation / Answer

Ans both C and D

C. In the absence of carnitine, fatty acids cannot be used for energy nor can ketone bodies be produced in large quantities; tissues like the muscle, heart, and brain can only use glucose under these conditions. This drives excessive glucose uptake from the blood, depleting glycogen stores in the liver and resulting in hypoglycemia.

D. In the absence of carnitine, fatty acid transport into the mitochondria requires a large amount of ATP; to produce the additional ATP required the liver must oxidize glucose, which depletes glycogen stores, causing hypoglycemia.

Explaination

  carnitine is play an important role in transporting the activated fatty acid into the mitochondia. Muscles weekness during prolonged exercise in a deficiency of  carnitine case because muscles depends on fatty acid as long term source of energy during fasting condition.

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