15. There are multiple possible explanations for how and why -oxidation might be
ID: 203823 • Letter: 1
Question
15. There are multiple possible explanations for how and why -oxidation might be blocked. Consider that there could be an inborn error in metabolism (a polymorphism in a gene coding for an enzyme in the pathway), a vitamin deficiency leading to the lack of enzyme action, or a problem with the transport of fatty acids into the mitochondria among other possibilities. You call your biochemistry professor up to ask for any ideas about how to proceed and she/he suggests that you consider looking at whether Jessie can metabolize short-chain fatty acids (12 or fewer carbons). When you ask why, your professor tells you to consult your book if you are unclear about what this might accomplish. What is different about the metabolism of short-chain fatty acids compared to long-chain fatty acids?
A. Short-chain fatty acids are not catabolized by -oxidation.Explanation / Answer
Answer B
Short-chain fatty acids do not require the carnitine shuttle to enter the mitochondria.
Because they bypass the extramitochondrial processes and the carnitine dependent transfer mechanism.
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