1. 1,25-dihydroxycholecalciferol: a. increases bone mineralization by increasing
ID: 203693 • Letter: 1
Question
1. 1,25-dihydroxycholecalciferol:
a. increases bone mineralization by increasing serum Ca levels
b. decreases bone reabsorption by antagonizing the action of PTH on bone
c. decreases serum phosphate levels by decreasing renal phosphate reabsorption
d. decreases serum alkaline phosphatase levels by decreasing bone turnover
2. Ketosis is not likely to occur in acromegaly because:
a. GH is not lipolytic hormone
b. GH inhibits beta oxidation
c. GH stimulates lipoprotein lipase
d. most individuals with acromegaly have sufficient insulin production to suppress ketosis.
Explanation / Answer
1. 1,25-dihydroxycholecalciferol:
a. increases bone mineralization by increasing serum Ca levels
b. decreases bone reabsorption by antagonizing the action of PTH on bone
c. decreases serum phosphate levels by decreasing renal phosphate reabsorption
d. decreases serum alkaline phosphatase levels by decreasing bone turnover
ANSWER is: b. decreases bone reabsorption by antagonizing the action of PTH on bone
EXPLANATION :
Increase in PTH results in release of calcium from bone whuch means bone reabsorption. This needs active form of vitamin D, 1,25-dihydroxycholecalciferol (1,25-DHCC). It helps in maintaining serum calcium normal by increasing calcium efflux from bone...
2. Ketosis is not likely to occur in acromegaly because:
a. GH is not lipolytic hormone
b. GH inhibits beta oxidation
c. GH stimulates lipoprotein lipase
d. most individuals with acromegaly have sufficient insulin production to suppress ketosis.
ANSWER is: b. GH inhibits beta oxidation
EXPLANATION :
The presence of excess of growth hormone in Acromegaly will impair the glucose metabolism
GH promotes lipolysis and decreases insulin sensitivity.
Growth hormones causes loss of fat but stimulates muscle gain. Growth hormones affects insulin signaling by decreasing insulin sensitivity.
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