C. Control of activity by inhibition and other means 1. Reversible inhibitors. A

Question

C. Control of activity by inhibition and other means 1. Reversible inhibitors. Assume that an enzyme, E, is inhibited by a molecule, I. Answer the following questions using the best choice(s) from among the following three terms. A correct answer may require you to choose more than one term. Hint: comparing how the three kinds of inhibitors affect a reciprocal plot will be helpful. 1.competitive inhibitor 2.uncompetitive inhibitor 3. noncompetitive inhibitor a) What kind of inhibitor is molecule I if its inhibition of the enzyme is overcome by high concentrations of substrate? b) What kind of inhibitor is molecule I if it increases the apparent K of the enzyme for its substrate? c) What kind of inhibitor is molecule I if the Va. of the enzyme is not decreased by 1? d) What kind of inhibitor is molecule I if the Va, of the enzyme is lowered by 1? e) What kind of inhibitor is molecule I if the K of the enzyme for its substrate is decreased by I?

Explanation / Answer

a) Competitive inhibitor

b) Competitive inhibitor

c) Competitive Inhibitor

d) Uncompetitive inhibitor and Noncompetitive inhibitor

e) Uncompetitive inhibitor

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