3. Incontinentia pigmenti (IP) is an X-linked dominant condition that is so seve

Question

3. Incontinentia pigmenti (IP) is an X-linked dominant condition that is so severe that affected males do not survive to be born. What is the probability that a woman with the condition will have a spontaneous abortion (AKA miscarriage)?
A. 0%
B. 75%
C. 100%
D. 50%
E. 25%

5. A woman with the X-linked dominant condition, congenital generalized hypertrichosis (CGH), has a daughter with dense facial and upper body hair. The woman's partner has normal upper body hair. If she becomes pregnant again, what is the probability that she will pass CGH on to her next daughter?
A. 0%
B. 25%
C. 50%
D. 100%
E. 75%

Explanation / Answer

Answer 3) Since the disease is X-linked dominant, there are 50 % chances that she will have miscarriage because if defected X chromosome is passed to male it will lead to miscarriage and if it passed to female progeny then it will lead to carrier female but alive.

Answer 5) There are 50% chances that the next daughter will be carrier of CGH disease. The cross are given below: Lets assume X is normal chromosome and Xo defected.

Xo X = daughter with disease, X Y = Normal male

First progeny after cross, Xo X, X X, XY and Xo Y.

So there are 50% chances of having daughter affected with disease.

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