BIO4763 Paper I Discussion DOl: https://doi.org/10.1016/j.cell.2007.08.046 Assig

Question

BIO4763 Paper I Discussion DOl: https://doi.org/10.1016/j.cell.2007.08.046 Assignment: Due 5pm on 28 Feburary. Must be submitted in PDF format via Blackboard. Paper will be discussed in class on 1 March. 1) In 3-5 sentences, describe the key findings of the paper. (3 points) 2) In 2-3 sentences, describe a question you had after reading the paper. This could be something you didn't understand, something that would be a follow up experiment, could be technical (how an experiment is performed), about trypanosome biology, etc.

Explanation / Answer

1. Key findings of the paper:
i. The clearance of IgG-VsG complex from the cell surface is unidirectional and it occurs prior to localized endocytosis.
ii. The rapid clearance of IgG-VSG complex on the trypanosome membrane protects the pathogen from complement mediated lysis.
iii. Cell motility is required for the clearance of IgG-VSG complexes on the cell surface.
iv. The rate of IgG-VSG complex clearance depends upon its size.

2. Further research/questions:
i. What is the mechanism by which trypanosome can clear immune complexes rapidly than the host antibody production.
ii. How hydrodynamic drag force can induce IgG-VSG complex movement?

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